PhD in Imaging and Molecular analysis of Takotsubo syndrome

OVERVIEW
We are looking for a candidate for a science thesis in Cardiovascular Imaging and Pharmacology. Our laboratory is interested in the non-destructive imaging analysis of energy metabolism and vascularization (Sourdon J et al. Theranostics 2017, Theranostics 2021). We have recently introduced a new non-invasive imaging technique to simultaneously study these two phenomena and their interactions (PETRUS, Provost J et al Nature Biomed Eng 2018, Perez-Liva M. et al. Phys Med Biol 2018, Mol Im Biol 2020, Facchin C et al. Theranostics 2020). Applied to the exploration of cardiac pathologies, the integration of PETRUS with molecular and functional analyses provides in-depth information on their mechanisms and pharmacological targets for treatment.

PROJECT
Takotsubo syndrome is a stress-induced cardiomyopathy affecting mostly women. The clinical picture is that of an infarction without coronary artery obstruction, its prevalence is increasing and it exposes to fatal recurrences. There is no treatment. We have identified the metabolic pathways involved, making them potential therapeutic targets. Our objective is to explore these new therapeutic avenues by in vivo imaging and proteomic and transcriptomic approaches.

LINES of RESEARCH
The main axes of this research topic are (1) to identify and/or confirm therapeutic targets by PETRUS imaging and molecular analysis, notably by Nanostring and p by mass spectroscopy, in order to (2) experimentally treat Takotsubo syndrome with drugs against the identified targets in the case of (a) a single stress and (b) repeated stress.
Work on small laboratory animals.

Master 2 en Sciences du Vivant

Willingness to pursue a career in medical research. • Good organizational skills • Relational skills • Rigor • Autonomy The ability to adapt in an international multidisciplinary team, scientific curiosity and motivation are essential.

Application to the PhD scholarship for 3 years: Doctoral School ED 563, deadline May 5, 2022 ; see http://parcc.inserm.fr/research-teams/team/tavitian/

Équipe de Recherche en Imageries du Vivant, Centre de Recherche Cardiovasculaire de Paris – PARCC _ Unité Inserm U970.
http://parcc.inserm.fr/research-teams/team/tavitian/